Principal Research Scientist II, Analytical Development

Company: AbbVie
Location: Worcester
Posted on: February 15, 2026

Job Description:

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok . Job Description The Opportunity We seek a Principal Scientist II, Analytical Development to join an experienced, fast-paced and collaborative team. This position will be primarily responsible for guiding the biophysical analytical strategy and developing novel analytical methods for characterizing AbbVies mRNA-based targeted lipid nanoparticles (tLNPs) pipeline. This role will manage a small team of scientists focused on biophysical methods for characterizing intact tLNPs and the targeting ligands. Working closely with the technology development and research teams, this position will guide development of novel characterization methods, drive process/product understanding, support expansion of the tLNP platform and pipeline, and support product investigations. Responsibilities & Duties: Lead strategy for and development of novel biophysical methods to characterize tLNP drug product and protein components, including but not limited to LC/CE/MS, DLS, MALLS, Nano flow cytometry, mass photometry, BLI, and plate-based assays Design and lead structure-activity relationship and extended characterization studies to improve tLNP function and stability Support product characterization for tLNP platform/formulation development and lead candidate selection Establish automation/lipid chromohigh throughput (HTP) workflows and in-process analytical methods for routine and non-routine testing of the tLNP pipeline Represent functional area in cross-functional pipeline and technology development teams. Effectively communicate complex technical topics to collaborators and management Support method transfer and qualifications as needed Manage and develop a team of 2-5 scientists Draft technical reports and documents as needed Qualifications Qualifications Bachelors Degree in Science related field with 16 years of related work; Masters Degree Science or PharmD with 14 years of related work; PhD in Science or related field with 8 years of related work experience Four years of experience managing direct reports and/or a functional team Degree in Biochemistry, Chemistry, Bioengineering, Chemical Engineering or related field with proven technical and leadership track record developing analytical characterization methods for nanoparticles (e.g. LNPs, viral vectors, etc) and biologics (e.g. antibodies, mRNA, etc) is required Experience developing analytical methods for nanoparticles (e.g. nano flow cytometry, mass photometry, NTA, AUC, etc.) and biologics (e.g. LC, CE, iCIEF, MS, MALLS, BLI, etc) is required Experience with method transfer and qualification is preferred Strong proficiency authoring and reviewing technical reports Familiarity with international regulatory standards and application to phase-appropriate analytical development and strategy is preferred Experience designing and executing stability and comparability studies is preferred Exceptional communication skills, both written and verbal, with a demonstrated capacity to thrive in collaborative, team-driven environments. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible to participate in our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: AbbVie, Warwick , Principal Research Scientist II, Analytical Development, Science, Research & Development , Worcester, Rhode Island